Expression and clinical significance of microRNA-106b-25 cluster in non-small cell lung cancer tissues
ZHU Yuntao
ZHANG Yanhong
YUAN Xueqin
GUO Xiaotong
ZHANG Zhiguo
Abstract：Objective To identify the expression level of microRNA-106b-25(miR-106b-25)cluster(miR-106b,miR-93 and miR-25)and further investigate its role in diagnosis and prognosis of non-small cell lung cancer(NSCLC).Methods Expression levels of miR-106b-25 were detected by qPCR in 60 primary tissue samples collected from patients with NSCLC,and the association between clinical characteristics and expression levels of miR-106b-25 cluster was also analyzed.Results Both miR-106b and miR-93 expression levels were significantly increased in primary tissues of NSCLC patients.Additionally,expression levels of miR-106b-25 cluster were positively correlated with tumor size,degree of differentiation,lymph node metastases,distant metastasis and TNM stage(P＜0.05).The area under the curve of miR-106b,miR-93 and miR-25 were 0.759,0.816 and 0.746,respectively.Moreover,the area under receiver operating characteristc curve of miR-106b-25 cluster was 0.826,significant higher than 0.717 of cytokeratin 19 fragment in the diagnosis of NSCLC.Kaplan-Meier survival analysis indicated that patients with high expression of miR-106b was associated with poor 5-year overall survival rate compared with patients with low expression of miR-106b(P=0.043).Conclusion MiR-106b-25 cluster express at a relative high level and miR-106b is a prognostic indicator for NSCLC patients.Thus,we believe that the miR-106b-25 cluster can be an important indicator for diagnosis and prognosis of NSCLC patients.
Keywords：Non-small cell lung cancerMicroRNA-106b-25 clusterDiagnosisPrognosis
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1189-1193 )