Expression and clinical significance of G protein-coupled estrogen receptor in malignant pleural effusion of lung adenocarcinoma
DU Yuansheng
AI Yiguo
HE Chunling
WEN Xuqing
XU Xiaohua
HUANG Haihua
Abstract：Objective To investigate the effect of G protein-coupled estrogen receptor(GPER)expression status in malignant pleural effusion due to lung adenocarcinoma on the outcome of patients treated with epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI).Methods Clinical data of lung adenocarcinoma patients who presented with malignant pleural effusion at the initial diagnosis in the Second Affiliated Hospital of Shantou University Medical College between January 1,2017 and December 31,2021 were retrospectively analyzed.Expression of GPER in the cell block of malignant pleural effusion origin of the patients was detected by immunohistochemistry,and the response to EGFR-TKI treatment was compared between patients with different GPER expression.Kaplan-Meier method and log-rank test were used to compare the difference in progression-free survival(PFS)of patients.The Cox proportional hazards model was constructed to analyze the independent risk factors affecting the PFS of the patients.Results Among 106 patients,68 were GPER positive and 38 were GPER negative.The objective response rate of GPER negative patients was higher than that of GPER positive patients[73.7％(28/38)vs.48.5％(33/68),x2=6.314,P=0.012],while the difference in disease control rate between GPER negative patients and GPER positive patients was not statistically significant[97.4％(37/38)vs.88.2％(59/68),P=0.092].Univariate analysis showed that the median PFS of GPER negative patients was 13.2 months,better than that of GPER positive patients at 10.6 months(P=0.035).Results of multivariate analysis showed that GPER positivity was an independent risk factor for PFS in lung adenocarcinoma patients with malignant pleural effusion(HR=2.041,95％CI:1.303-3.196,P=0.002).Conclusion High expression of GPER in advanced lung adenocarcinoma with malignant pleural effusion is a negative predictor of EGFR-TKI efficacy in these patients and may be a potential predictive biomarker and therapeutic target.
Keywords：Lung adenocarcinomaG protein coupled estrogen receptorEpidermal growth factor receptor tyrosine kinase inhibitorMalignant pleural effusionEstrogen
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1183-1188 )