Progress in the application of NK cell immunotherapy in ovarian cancer
CHEN Qingyu
ZHANG Jie
ZHOU Meixiang
MIN Daliu
Abstract：Objective Natural killer(NK)cells are an important component of innate immune cells and have significant potential in the field of tumor therapy.NK cells can not only directly recognize ovarian cancer cells and use their strong cytotoxic effects to kill them,but also activate anti-tumor immune responses,indirectly exerting anti-cancer effects.Currently,with the rapid development of NK cell adoptive reinfusion and chimeric antigen receptor(CAR)-NK cells,NK cell immunotherapy has become an important strategy for targeted treatment of ovarian cancer.Therefore,this article provides a detailed introduction to the phenotype,immunological characteristics,and anti-tumor mechanisms of NK cells.At the same time,the latest progress of NK cell immunotherapy in the treatment of ovarian cancer was reviewed from multiple aspects,including NK cell adoptive infusion,CAR-NK cell therapy,antibody dependent cytotoxicity(ADCC)pathway,and NK cell activity regulation,in order to provide theoretical basis for the clinical application of NK cell immunotherapy.
Keywords：Ovarian cancerNatural killer cellsImmune cellsImmunotherapy
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1121-1125 )