Research progress of hypoxia-inducible factor α hydroxylation in invasion and metastasis of liver cancer
XU Zuoming
NIAN Jiahui
WANG Xingzhizi
PU Jian
Abstract：Liver cancer,as a common malignant tumor,presents a significant challenge in treatment due to its high malignancy and propensity for metastasis.Therefore,investigating the molecular mechanisms underlying invasion and metastasis of liver cancer is of paramount importance.In this regard,hypoxia-inducible factor α(HIF-α)has emerged as a key regulatory factor,with its hydroxylation level found to be closely associated with the invasion and metastasis of liver cancer.Understanding the biological significance of HIF-α hydroxylation levels can provide deeper insights into its role in the development of liver cancer.This review will focus on regulatory mechanisms of HIF-α hydroxylation in invasion and metastasis of liver cancer,aiming to offer new perspectives and strategies for liver cancer treatment.
Keywords：Liver cancerHypoxia-inducible factor αHydroxylation
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 914-917 )