Correlation between PD-L1 expression in circulating tumor cells and immunotherapy efficacy in non-small cell lung cancer
WU Qiuxia
WANG Qin
CHEN Mo
ZHAN Ping
LU Wanjun
ZOU Heng
SONG Yong
Abstract：Objective To investigate the detective rate of circulating rumor cells(CTCs)of non-small cell lung cancer(NSCLC)patients,and the relationship between the expression of programmed death ligand 1(PD-L1)on CTCs and the efficacy of immunotherapy.Methods Clinical features,CTC 100 platform detection information,PD-L1 expression,treatment and outcome data were collected in 20 NSCLC patients from January 2022 to November 2022.Wilcoxon rank sum test was used for difference analysis,Kappa test for consistency analysis,Spearman test for correlation analysis,and Kaplan-Meier plotted survival curve.Results Among the 20 patients,the baseline detection rate of CTCs was 80%,and the baseline detection rate of PD-L1 positive CTCs was 50%.The overall detection rate of CTCs was 80%,and the overall detection rate of CTCs in PD-L1 positive patients was 42.5%.There is no consistency between PD-L1 CTCs test results and PD-L1 immunochemistry test results.The expression level of CTCs PD-L1 was not correlated with immunotherapy efficacy and prognosis.Conclusion CTC100 platform has a high detection rate,which provides a new method for clinical detection of CTCs.No correlation is found between CTCs PD-L1 expression level and immunotherapy efficacy and prognosis in NSCLC patients.
Keywords：Non-small cell lung cancerCirculating tumor cellProgrammed cell death ligand 1Microfluidic chipImmunotherapy
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 844-849 )