Current clinical application and research progress of lomustine in the treatment of malignant tumors
YANG Fan
QIN Shukui
Abstract：Lomustine(CCNU)is a classic nitrosylurean alkylating agent,which is orally administered and has good fat solubility and blood-brain barrier penetration,and can be used for a variety of malignant tumors with good efficiency.CCNU combined with radiotherapy and other anti-tumor drugs(temozolomide,bevacizumab,etc.)is effective and safe in the treatment of brain glioma.CCNU is also commonly used for some other malignant tumors,such as lymphoma,elderly acute myeloid leukemia,melanoma and etc.Its effectiveness and tolerance have been fully demonstrated in the clinical practice and a number of studies.This review focuses on the current status of CCNU in the treatment of malignant tumors and the progress of relevant studies in recent years,which provides an important reference for clinicians when using CCNU.
Keywords：Malignant tumorLomustineTreatmentResearch progress
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 805-811 )