Analysis of adverse reactions caused by anti-angiogenesis drugs combined with chemotherapy in osteosarcoma and soft tissue sarcoma
ZHOU Yingling
ZHANG Zihao
WANG Xiaolu
LIU Baorui
LI Rutian
Abstract：At present,the combination of anti-angiogenic drugs and chemotherapy is a new direction in the treatment of osteosarcoma and soft tissue sarcoma.The combination of targeted drugs and chemotherapy will produce synergistic effects and improve the therapeutic effect.However,the side effects caused by combined therapy are often more severe than those caused by targeted therapy or chemotherapy alone,especially the occurrence of severe side effects should not be ignored.Therefore,clinicians should be familiar with the adverse events that may occur in combined therapy and give patients timely and effective treatment.This review summarizes some common adverse events in combined therapy for advanced sarcoma patients,comprehensively analyzes the published clinical data,and compares the incidence of adverse events between targeted therapy and combined chemotherapy,in order to help clinicians to improve the understanding of common adverse events in combind therapy,better grasp the safety of medication for sarcoma patients,so as to obtain safer and more effective treatment and improve the quality of life.
Keywords：OsteosarcomaSoft tissue sarcomaAnti-angiogenic drugsAdverse effectsChemotherapy
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 96-101 )