Levels and clinical significances of CISD1 and CISD2 in breast cancer tissues
BAO Yanhong
LIU Xiaohua
XUE Dingwen
GAO Fan
WANG Lei
Abstract：Objective To investigate the levels and clinical significances of CDGSH iron sulfur domain 1(CISD1)and CDGSH iron sulfur domain 2(CISD2)in breast cancer tissues.Methods Eighty-seven pairs of breast cancer tissues and paracancerous tissues surgically removed from January 2020 to December 2021 were collected.Real-time quantitative PCR was used to detect the tissue CISD1 and CISD2 levels and analyze their relationships with the clinicopathological characteristics of breast cancer.The Kaplan-Meier Plotter database was used to analyze the relationship of CISD1 and CISD2 levels with prognosis online.Results The levels of CISD1 and CISD2 in 87 cases of breast cancer tissues were 4.689±0.169 and 4.708±0.214,higher than 1.365±0.072 and 1.518±0.074 in adjacent tissues with statistically significant differences(t=18.114,14.092,P<0.001).Linear regression analysis showed that the levels of CISD1 and CISD2 in breast cancer tissues were positively correlated(r = 0.516,P<0.001).Stratified analysis revealed that the levels of CISD1 and CISD2 in tissues were not correlated with age,menopause,histological grade,ER expression,PR expression and HER-2 expression(P>0.05),while CISD1 level was correlated with tumor size,TNM stage and Nottingham prognosis index(P<0.05),and CISD2 level was correlated with tumor size,lymph node metastasis and TNM stage(P<0.05).Kaplan-Meier Plotter online analysis showed that the CISD1 level was related to the recurrence free survival(RFS),overall survival(OS)and distant metastasis free survival(DMFS)of breast cancer(P<0.05),and the upper quartile of the low level group was better than the high level group.However,the CISD2 level was not related to RFS,OS and DMFS of breast cancer(P>0.05).Conclusion The upregluation of CISD1 and CISD2 is involved in the occurrence and development of breast cancer and CISD1 is closely related to the prognosis of breast cancer,which is expected to become a target for prevention and treatment of breast cancer.
Keywords：Breast cancerCDGSH iron sulfur domain 1CDGSH iron sulfur domain 2Clinical significance
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1008-1012 )