Progress in the application of immune checkpoint inhibitors in gastric cancer
GE Kele
FANG Cheng
WU Jun
Abstract：Immunotherapy has become an indispensable part of cancer treatment, and immune checkpoint inhibitors have claimed a major role. Immunocheckpoint refers to some inhibitory signaling pathways in the immune system, whose activation can inhib-it autoimmunity, prevent the occurrence of autoimmune diseases under physiological conditions, and facilitate the escape of tumor cells under pathological conditions. Currently, immune checkpoint inhibitors mainly include anti-cytotoxic T-lymphocyte associated protein 4, anti-programmed death-1 and anti-programmed death ligand-1 antibodies. Immune checkpoint inhibitors have benefited numerous melanoma and lung cancer patients, and breakthroughs have also been made among gastric cancer patients. This article reviews the lat-est research progress in the treatment of gastric cancer with immune checkpoint inhibitors.
Keywords：Gastric cancerImmune checkpoint inhibitorsCytotoxic T-lymphocyte associated protein 4Programmed death-1
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1050-1054 )