Expression and clinical significance of MNK1 in non-small cell lung cancer tissues
WANG Hongzhi
CHEN Zhenxiang
ZHANG Yu
LI Tao
WANG Shuangyue
Abstract：Objective To investigate the expression and clinical significance of MAPK interacting serine／threonine kinase 1 (MNK1) in non-small cell lung cancer (NSCLC) tissues. Methods From March 2014 to June 2018, 79 pairs of cancer tissues and matched adjacent tissues of NSCLC patients were collected. The MNK1 level in the above tissues was detected by real-time quantitative PCR, and the relationship between MNK1 level and clinicopathological characteristics of NSCLC was analyzed. The relationship between MNK1 level and overall survival (OS) was analyzed by Kaplan-Meier method. Cox risk ratio model was used for multivariate a-nalysis. Results The MNK1 level in NSCLC tissues was 4. 668±1. 264, higher than 1. 438±0. 577 in paracancer tissues (P＜0. 05). The expression of MNK1 was not related to sex, age, smoking history and pathological type of NSCLC (P＞0. 05), but related to tumor size, lymph node metastasis and TNM stage ( P＜0. 05). The median OS of the patients with high expression of MNK1 was 37. 0 months, and the median OS of the patients with low expression was not reached. The median OS of patients with low expression was lon-ger than that of patients with high expression (P＜0. 05). Multivariate analysis showed that MNK1 expression was an independent factor affecting the prognosis of NSCLC ( OR＝2. 785, 95%CI: 1. 506-5. 941, P＜0. 05). Conclusion The high expression of MNK1 in NSCLC is an indicator of high malignancy and poor prognosis of NSCLC, which provides guidance for early diagnosis and prognosis e-valuation of NSCLC patients.
Keywords：Non-small cell lung cancerMAPK interacting serine／threonine kinase 1Clinical significancePrognosis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1019-1022 )