The development of comprehensive treatment on melanoma brain metastases
DONG Yong
SUN Jiping
LOU Fang.
Abstract：The poor prognosis of advanced malignant melanoma is strongly associated with its highly brain metastasis rates and poor therapeutic effects. Recently, new small molecular targeted drugs(BRAF inhibitors and MEK inhibitor) as well as immunotherapy (anti?CTLA?4 antibodies, anti?PD?1／PD?L1 antibodies), started to treat advanced malignant melanoma. These new drugs bring new hopes to improve the prognosis of melanoma brain metastases. In this paper, we reviewed the latest development of melanoma brain me?tastasis treatment in radiotherapy, chemotherapy, small molecule targeted drug therapy, immunotherapy and combination therapy in or?der to find out a better assessment for melanoma brain metastases.
Keywords：Malignant melanomaBrain metastasesTargeted therapyImmunotherapy
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 948-953 )