Expression and clinical significance of MALAT1 and fibroblast growth factor 2 in thyroid micropapillary carcinoma
HAN Zhirong
FENG Zejin
HAN Liang
HU Yuezhen
Abstract：Objective To analyze the expression of long?chain non?coding RNA ( lncRNA) MALAT1 and fibroblast growth factor 2 (FGF2) in thyroid micropapillary carcinoma (PTMC) and their relationship with the clinicopathological characteristics of PT?MC. Methods Cancer tissues and adjacent normal tissues of 63 patients with PTMC who underwent surgical treatment from September 2014 to February 2018 were collected. Real?time fluorescence quantitative PCR (QPCR) was used to detect the expression of MALAT1 and FGF2. The correlation between the expression of MALAT1 and FGF2 was analyzed. The relationship between the expression of MALAT1 and FGF2 and the clinicopathological features of PTMC was analyzed. Results The expression level of MALAT1 in PTMC tissues was 3. 54±0. 10, which was higher than 1. 04±0. 05 in normal tissues adjacent to cancer; the expression level of FGF2 in PTMC tissues was 2. 78±0. 10, which was higher than 0. 97±0. 05 in normal tissues adjacent to cancer. The difference was statistically signifi?cant (P＜0. 05). The expression of MALAT1 and FGF2 in PTMC was positively correlated (r＝0. 738, P＝0. 001). The expression of MALAT1 was correlated with tumor size and capsular invasion (P＜0. 05); and the expression of FGF2 was correlated with tumor size, number of lesions, bilateral lesions, central lymph node metastasis, capsular invasion and NT (P＜0. 05). Conclusion High expres?sion of MALAT1 and FGF2 in PTMC is closely related to proliferation, metastasis and invasion of tumors.
Keywords：Papillary thyroid microcarcinoma ( PTMC )Long non?coding RNA?MALAT1 ( lncRNA?MALAT1 )Fibroblast growth factor 2(FGF2)Clinicopathological features
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 804-807 )