Expression and clinical significance of PTGER4 in retinoblastoma tissues
WANG Duqin
WAN Li
QIN Xuewei
ZHANG Daoyuan
WANG Qianhan
Abstract：Objective To investigate the expression of prostaglandin E2 receptor 4 ( PTGER4) in retinoblastoma ( Rb) tis-sues and its clinical significance. Methods From January 2012 to December 2016, 67 Rb tissues with complete clinical data and 21 normal retinal tissues were collected. The expression of PTGER4 in the above tissues was detected by real-time quantitative PCR and immunohistochemistry. The relationship between expression of PTGER4 and clinicopathological parameters ( age, sex, side, IIRC stage, pathological differentiation and optic nerve infiltration) of Rb was analyzed.Results PTGER4 expression level and positive rate in 67 Rb tissues were 2. 653±1. 056 and 56. 7%(38／67), higher than 1. 027±0. 346 and 28. 6%(6／21) in normal retina tissues with significant difference (P＜0. 05). The expression of PTGER4 in Rb was not related to age, sex and side, but related to IIRC stage, pathological differentiation and optic nerve infiltration. The PTGER4 level and positive expression rate were higher in the corresponding tissues with advance IIRC stage, low undifferentiated and optic nerve infiltration (P＜0. 05). Conclusion PTGER4 expression is in-creased in Rb tissues, which is related to the IIRC stage, pathological differentiation and optic nerve infiltration of Rb.PTGER4 can be used as a potential index for judging Rb infiltration and evaluating the condition of Rb.
Keywords：RetinoblastomaProstaglandin E2 receptor 4Clinical stagePathological differentiation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 727-731 )