Expression and clinical significance of SOX21?AS1 in non?small cell lung cancer tissues
SHI Xiangying
MAO Yawei
WANG Zhengwei
ZHANG Yuming
ZHANG Hao
Abstract：Objective To investigate the expression and clinical significance of SOX21 antisense RNA 1 ( SOX21-AS1) in non-small cell lung cancer (NSCLC) tissues.Methods Ninety-four pairs of NSCLC patients??cancer tissues and matched adjacent tissues were collected from September 2014 to June 2017. The levels of SOX21-AS1 in the above tissues were detected by real-time quantitative polymerase chain reaction ( QPCR). The relationship between SOX21-AS1 level and clinicopathological characteristics ( sex, age, smoking history, tumor size, lymph node metastasis, TNM stage and disease) were analyzed.According to the follow-up data, the progno-sis of NSCLC patients with different SOX21-AS1 levels was analyzed. Results The level of SOX21-AS1 in NSCLC tissues was 3. 870± 1. 200, higher than 1. 215±0. 565 in adjacent tissues (P＜0. 05).Receiver operating characteristic curve analysis showed that the area un-der curve of tissue SOX21-AS1 level in diagnosis of NSCLC was 0. 986 (95% CI: 0. 975-0. 998), and the Yoden index was the highest (0. 904) when the threshold value was 2. 017 with the sensitivity and specificity of 95. 74% and 94. 68%. The median of SOX21-AS1 in 94 NSCLC tissues was 3. 843, which was divided into 47 cases with low expression (＜3. 843) and 47 cases with high expression (＞3. 843). The results showed that SOX21-AS1 expression was not related to sex, age and smoking history of NSCLC, but to tumor size, lymph node metastasis, pathological type and TNM stage (P＜0. 05).SOX21-AS1 levels were higher in patients with positive nodal metas-tasis, larger tumors and later clinical stages. The median overall survival of high expression of SOX21-AS1 was 31. 5 months, lower than 47. 0 months of low expression (P＜0. 05). Multivariate analysis showed that the overexpression of SOX21-AS1 was an independent factor for the poor prognosis of NSCLC ( HR＝2. 153, 95% CI: 1. 657-4. 156, P＜0. 05). Conclusion SOX21-AS1 is highly expressed in NSCLC tissues and participates in the occurrence and development of NSCLC.The prognosis of NSCLC patients with high level of lncRNA is poor. SOX21-AS1 can be used as a potential molecular diagnostic and prognostic marker for NSCLC.
Keywords：Non-small cell lung cancerLong-chain non-coding RNASOX21 antisense RNA 1Clinical significance
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 706-710 )