New advances in immonotoxin: Combination of tumor targeted therapy and immunotherapy
WEI Xiao
CHEN Fangjun
XIN Kai
LIU Qin
LI Lin
YU Lixia
LIU Baorui.
Abstract：Immunotoxins are chimeric proteins with a toxin moiety linked or genetically fused to a targeting moiety and can target cancer cells. The clinical applications of traditional immunotoxins are disappointing due to their high immunogenicity and poor penetrability. Nowadays genetic recombination technology has been employed to overcome the historical challenge of traditional immuno?toxins, allowing recombination immunotoxins (RITs) to be developed again and applied for various malignancies.However, the issue of immunogenicity is remaining and shows a negative correlation with clinical efficacy. Thus future researches focus on developing new strategies to modify immunotoxins that reduce immunogenicity. The review summarizes the current state and progress of immunotoxins.
Keywords：TumorTargeted therapyImmunotherapyImmunotoxinsRecombination immunotoxins
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 643-648 )