Expression and clinical significance of miRNA-138-5p in non-small cell lung cancer
ZHANG Ning
LU Chuangxin
WU Sen
HE Yi
WEI Li
Abstract：Objective To investigate the expression and significance of miRNA-138-5p (miR-138-5p) in non-small cell lung cancer (NSCLC). Methods Real-time fluorescence quantitative PCR (QPCR) was used to detect the expression of miR-138-5p in102 NSCLC tissues and 98 paracancerous tissues. The relationship between the expression of miR-138-5p and the clinicopathological features of NSCLC (sex, age, TNM stage, tumor size and lymph node metastasis) were analyzed. The survival curve was drawn by Kaplan-Miere method, and the difference was checked by Log-rank test. Cox regression model was used to analyze the factors affecting overall survival (OS). Results The expression level of miR-138-5p in NSCLC tissues was 0. 42±0. 11, significantly lower than 1. 03 ±0. 28 in adjacent tissues (P＜0. 05). The expression of miR-138-5p was correlated with TNM stage, tumor size and lymph node metastasis (P＜0. 05). The median OS of high expression of miR-138-5p was more than 36 months, which was significantly higher than that of low expression of miR-138-5p (P＜ 0. 05). Cox univariate analysis showed that besides the expression of miR-138-5p, lymph node metastasis, tumor size and TNM stage were also associated with OS (P＜0. 05). Conclusion The expression of miR-138-5p is downregulated in NSCLC, which is related to the development and prognosis of NSCLC. MiR-138-5p can be used as a new target for diagnosis and prognosis prediction of NSCLC.
Keywords：Non-small cell lung cancer (NSCLC)miRNA-138-5pPrognosis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 149-152 )