Preoperative diagnostic value of magnetic resonance T2WI peritumoral edema for early recurrence of invasive breast cancer

WANG Gang; ZHANG Guofu

doi:10.3969/j.issn.1009-0460.2019.01.012

Abstract：Objective To investigate the diagnostic value of magnetic resonance T2 WI peritumoral edema signs in early recurrence of invasive breast cancer. Methods The clinical data of 116 patients with invasive breast cancer in our hospital were retrospectively analyzed. According to the signs of peritumoral edema on T2 WI, the patients were divided into positive group and negative group. The clinicopathological features of invasive breast cancer and the relationship between the postoperative early recurrence and preoperative peritumoral edema on T2 WI were compared. Kaplan-Miere method was used to draw the survival curve of disease free survival, and Cox risk proportional model was used to analyze the factors affecting recurrence of breast cancer after operation. Results Peritumoral edema on T2 WI was positive in 39 cases and negative in 77 cases. Compared with the negative group of peritumoral edema on T2 WI, the positive group had higher T stage and N stage, higher Ki-67 expression rate and lymphatic infiltration rate, lower ER/PR and HER-2 positive rate (P ＜ 0. 05). The three-year disease-free survival rates of the positive and negative groups with T2 WI peritumoral edema sign were 56. 4％ and 89. 6％, with significant difference (P ＜ 0. 05). Univariate analysis showed that T stage, N stage, lymphatic vessel infiltration and peritumoral edema sign of T2 WI were associated with early recurrence of breast cancer after operation (P ＜ 0. 05). Multivariate analysis showed that positive peritumoral edema sign of T2 WI (HR = 3. 226, 95％ CI: 1. 033-10. 078, P =0. 044) and N2-N3 (HR = 3. 477, 95％ CI: 1. 122-10. 775, P = 0. 031) were independent risk factors for early recurrence of invasive breast cancer. Conclusion Preoperative MR T2 WI signs of peritumoral edema have great predictive value for early recurrence of invasive breast cancer.