The meta-analysis of the efficacy of Shengbai mixture in the treatment of bone marrow suppression after chemotherapy for malignant tumors
MIAO Xianyuan
WANG Xiaojia
Abstract：Objective To analyze the clinical efficacy of Shengbai mixture in the treatment of bone marrow suppression after chemotherapy for malignant tumors, and to provide reference for clinical medication. Methods The literatures of Chinese academic journal network full-text database, Wanfang database and Weipu Chinese medical journal were systematically searched, and the clinical research literature on the efficacy of Shengbai mixture in the treatment of bone marrow suppression after chemoradiotherapy for malignant tumors was studied. Meta-5. 0 software was used for meta-analysis. Results A total of 7 articles were included, and the cumulative number of trials was 3310. The meta-analysis showed that the effect of Shengbai mixture on bone marrow suppression after chemotherapy was significant (OR = 9. 36, 95％ CI: 7. 82-11. 20, P ＜ 0. 001). Subgroup analysis showed that the clinical efficacy of Shengbai mixture for 9 days or 14 days was better than that of taking Shengbai mixture until interruption or discontinuation of chemotherapy (OR = 10. 06, 95％ CI: 8. 35-12. 13, P ＜ 0. 001; OR = 4. 19, 95％ CI: 2. 18-8. 06, P ＜ 0. 001). Two evaluation criteria of therapeutic effect showed that Shengbai mixture could effectively treat bone marrow suppression after chemotherapy for cancer (OR = 8. 12, 95％CI: 6. 66-9. 91, P ＜ 0. 001; OR = 6. 42, 95％ CI: 4. 52-9. 12, P ＜ 0. 001). Conclusion Shengbai mixture has obvious effect on bone marrow suppression after chemotherapy for malignant tumors. It is safe in clinical use and has no obvious side effects.
Keywords：Shengbai mixtureChemotherapyMyelosuppressionMeta-analysis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 54-59 )