Application and research progress of radiotherapy in gastrointestinal stromal tumors
CHEN Duke
TAN Xingying
WANG Ying
ZHANG Tao
Abstract：Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, which is thought to be insensitive to radiotherapy, so radiotherapy is rarely used in GIST.At present, studies have shown that GIST is not generally resistant to radiotherapy and radiotherapy related side effects of grade 3 or above occur at a low incidence, so application of the appropriate dose of radiation to a large extent can relieve symptoms and improve local control rate.As the first choice for non-surgical treatment towards advanced GIST, tyrosine kinase inhibitor can enhance the radiotherapy sensitivity by inhibiting ERK signal transduction pathway and excessive expression of RAD51 protein, attenuating DNA damage repair.The combined use of radiotherapy and tyrosine kinase inhibitor may increase clinical benefit.In this article, the current application of radiotherapy in gastrointestinal stromal tumors and research progress were reviewed.
Keywords：Gastrointestinal stromal tumorRadiotherapyTyrosine kinase inhibitor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1145-1148 )