Clinical analysis of 32 cases of esophageal small cell carcinoma
XIANG Dan
CHEN Yitian
XU Yichen
HAN Siqi
Abstract：Objective To analyze the clinicopathological features and treatment of primary esophageal small cell carcinoma (PESC), and explore the factors affecting the prognosis.Methods The clinical data of 32 patients with PESC diagnosed by pathology from January 2010 to December 2016 were analyzed retrospectively.Kaplan-Meier method was used to calculate the survival.Cox risk regression model was used to analyze independent prognostic factors affecting overall survival (OS). ResultsThe OS of 32 patients with PESC was 2.2-62.2 months, and the median OS was 23.8 months.Univariate analysis showed that the length of esophageal lesion, TNM stage, VALSG stage and ECOG were associated with prognosis (P＜0.05). Cox multivariate analysis showed that TNM stage (RR=2.679, 95％CI:1.444-4.969, P=0.002) and esophageal lesion length (RR=3.699, 95％CI:1.095-12.499, P=0.035) were independent prognostic factors for OS.The OS of operation combined with radiotherapy combined chemotherapy group was better than that of radiotherapy and chemotherapy group (P=0.014) and simple therapy group (P=0.001). ConclusionPESC is rare in clinic.Its preoperative diagnosis rate is low and prognosis is very poor.Surgical treatment is helpful to prolong the survival of patients.
Keywords：Esophageal small cell carcinomaEpidemiologySurvivalPrognosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1114-1117 )