Survival and prognostic factors analysis of stage N2-Ⅲ A non-small cell lung cancer patients treated with surgery
TIAN Cuimeng
ZHANG Xu
XIA Guangrong
XU Yongxiang
LIU Guimei
Abstract：Objective To investigate the survival and its related factors of the patients with stage N2-ⅢA non-small cell lung cancer (NSCLC) after surgery.Methods From October 2010 to June 2013 in Beijing Chest Hospital, 119 patients with pathological N2-ⅢA NSCLC after resection were enrolled.Kaplan-Meier analysis and Cox multivariate regression analysis were used to evaluate the overall survival (OS), progression-free survival (PFS), pulmonary PFS and its related factors.Results Until the end of follow-up, the1, 3, 5-year survival rates and median OS were 88.2％、53.8％、35.7％and 43 months (95％CI:31.49-54.51months), respectively.Kaplan-Meier single factor analysis revealed that N2classification, postoperative adjuvant chemotherapy, postoperative adjuvant radiotherapy (PORT) were the independent factors for OS, PFS and pulmonary PFS.Cox regression analysis revealed that N2classification and PORT were the independent factors for OS, the OS of N2a2, N2band no PORT patients was short compared with N2a1and PORT patients, and the risk of death was 2.279, 2.841 and 1.959 times respectively (P＜0.05). N2classification, postoperative adjuvant chemotherapy and PORT were independent factors for PFS and pulmonary PFS.Kaplan-Meier analysis was used to evaluate the OS, PFS, pulmonary PFS with PORT or no PORT.The results showed that there was no significant difference in OS, PFS and pulmonary PFS among patients with single station N2metastasis (P＞0.05). While there were significant difference in OS, PFS and pulmonary PFS among patients with multiple station N2metastasis (P＜0.05). Conclusion N2classification is the important prognostic factors of stage N2-ⅢA NSCLC patients treated with surgery.Postoperative adjuvant chemotherapy and PORT can improve local control and longterm survival, and PORT is indispensable for multiple station involved N2.
Keywords：Non-small cell lung cancerStage N2-ⅢARadical resectionPrognostic analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1107-1113 )