Predictive biomarkers to antiangiogenesis therapies
XING Lijun
HUANG Wei
Abstract：The development of new blood vessels not only serves to supply the tumor tissue with nutrients,but they can also serve as a means for cancer cells to metastasize. Anti-angiogenic therapy for cancer has gradually become an important way of cancer therapy. The widespread use of anti-angiogenic drugs in clinical practice not only brings benefits to patients but also brings side effects and economic burdens. Therefore more and more researches on predictive biomarkers to anti-angiogenesis therapies have been carried out. Some studies have found that vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor (VEGFR) pathway related factors,cytokines of CXC chemokine family and other angiogenic regulators can predict the efficacy of anti-angiogenic drugs. However,the conclusions of different studies are not exactly the same,and the related predictors are not widely accepted. This article reviews the predictive effects of biomarkers on anti-angiogenic drugs.
Keywords：BiomarkerAnti-angiogenic drugsEffectPredictor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 952-956 )