Predictive model of recurrence and metastasis after chemoradiotherapy of non-small cell lung cancer
XIA Shiwang
AI Tiantian
LI li
Abstract：Objective To explore the factors influencing recurrence and metastasis of non-small cell lung cancer (NSCLC) after radiotherapy and chemotherapy,and establish predictive model of recurrence and metastasis. Methods Clinical data of 187 pa-tients with NSCLC treated with radiotherapy and chemotherapy from January 2013 to January 2017 were collected. All patients were di-vided into non-recurrent group and relapsed group,as well as non-metastasis group and metastasis group. The relationship of clinico-pathological features (gender,age,hemoglobin,platelet,CEA,clinical stage,T stage,N stage,vascular invasion,pathological type, differentiation,AFP,chemotherapy cycles,treatment patterns)with recurrence and metastasis were analyzed. Univariate and multiva-riate Logistic regression analysis were performed to determine the influencing factors for recurrence and metastasis of NSCLC after radio-therapy and chemotherapy. The receiver operating characteristic (ROC)curve was generated for multivariate Logistic regression analy-sis. Results Among 187 patients,there were 146 relapses (78.1%)and 105 metastases (56.1%). Hemoglobin,platelet,CEA, clinical stage,T stage,N stage,vascular invasion,pathological differentiation degree,chemotherapy cycles and treatment patterns were related to recurrence and metastasis. Univariate Logistic regression analysis showed that hemoglobin,CEA,clinical staging,T stage,N stage,vascular invasion,differentiation,chemotherapy cycles and treatment methods were factors influencing the recurrence of NSCLC;platelets,CEA,clinical stage,T stage,N stage,vascular invasion,differentiation,chemotherapy cycles and treatment patterns influenced the metastasis of NSCLC. Multivariate Logistic regression analysis showed that CEA,clinical stage,differentiation, chemotherapy cycles and treatment patterns were independent factors influencing recurrence;CEA,clinical stage,differentiation and chemotherapy cycles were independent factors influencing metastasis of NSCLC. The AUC of NSCLC recurrence and metastasis was 0.867 (0.738-0.913)and 0.813 (0.722-0.895). Conclusion CEA,clinical stage,differentiation,chemotherapy cycles and treat-ment patterns are closely related to the recurrence and metastasis of NSCLC. Preventive measures should be taken to reduce the occur-rence and metastasis previously.
Keywords：Non-small cell lung cancer(NSCLC)ChemotherapyRadiotherapyRecurrenceMetastasisPredic-tive model
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 920-924 )