Expression of UHRF1 in cervical cancer and its clinical significance
HUANG Xin
JIANG Jiyong
LIU Lili
DENG Xiaopeng
CHAI Liya
Abstract：Objective To investigate the expression of UHRF1 in cervical cancer and its clinical significance. Methods From January 2013 to June 2016, 89 cases of cervical cancer, 68 cases of normal cervical tissue and 109 cases of cervical intraepithelial neoplasia (CIN),including 29 cases of CIN I,33 cases of CIN Ⅱ and 47 cases of CIN Ⅲ, were collected. The expression of UHRF1 in the above tissues was detected by real-time quantitative PCR (QPCR). The relationship between the expression of UHRF1 and the clinicopathological parameters of cervical cancer (age, lymph node metastasis, FIGO staging, tumor size,histological grade and pathological type) was analyzed. The receiver operating characteristic curve (ROC) was used to analyze the value of UHRF1 in the diagnosis of different cervical lesions. Results The level of UHRF1 in cervical cancer tissues was 3.086±2.327,which was higher than that of normal cervical and CIN tissues,and the difference was statistically significant (P<0.05). The expression of UHRF1 was not related to age, lymph node metastasis and pathological type (P>0.05),but associated with FIGO stage and histological grading (P<0.05). The expression level of UHRF1 in stage Ⅱ-Ⅲ was 3.793±2.410,higher than 1.764±1.443 in stage I,and the expression level of UHRF1 in G2-G3 stage was 3.811±2.330, higher than that 1.230±0.784 in G1 stage (P<0.05). ROC curve analysis showed that AUC of UHRF1 to distinguish cervical cancer from normal cervix, CIN and all subjects were 0.803 (sensitivity 69.66％, specificity 85.29％),0.734 (sensitivity 66.29％, specificity 73.39％) and 0.760 (sensitivity 66.29％,specificity 79.10％). Conclusion UHRF1 is highly expressed in cervical cancer tissue, and is related to histological grade and FIGO stage. It is effective in diagnosing cervical cancer. It may become a new molecular marker for diagnosis and prediction of cervical cancer.
Keywords：Cervical cancerUHRF1Clinical significanceDiagnostic efficacy
Publication Date：2018-01-01
Pages：5( 137-141 )