Prognostic analysis of thoracic esophageal carcinoma patients with stage pT2-3N0-1M0 after surgery
LIU Yanhu
XUE Dong
LI Juan
TAN Zhenguo
Abstract：Objective To investigate the survival and its related factors of the patients with pathological stage pT2-3N0-1M0 thoracic esophageal squamous cell carcinoma after resection.Methods From January 2011 to March 2014 in the Second Affiliated Hospital of Nanjing Medical University,127 patients with pathological stage pT2-3N0-1M0 thoracic esophageal squamous cell carcinoma after resection were enrolled.Kaplan-Meier analysis and Cox multivariate regression analysis were used to evaluate the postoperative survival and its related factors.Nomogram model was applied to implement for 1-,3-,5-year survival rate of individual patients.Results Until the end of follow-up,the 1-,3-,5-year survival rates and median overall survival (OS) were 81.8％,54.3％,38.4％ and 40.0 months(95％CI:32.285-47.715),respectively.Cox multivariate analysis revealed that stage pT(pT2 and pT3),pN (pN0 and pN1),intravascular cancer embolus and tumor diameter(≤ 3 cm and＞3 cm) were the independent factors for OS,risk ratios of pT3,pN1,intravascular cancer embolus and tumor diameter＞3 cm were 2.207,2.157,1.758 and 1.607 (P＜0.05).Nomogram model could accurately predict the survival rate of pathological stage pT2-3N0-1M0 thoracic esophageal squamous cell carcinoma.Conclusion The survival of thoracic esophageal squamous cell carcinoma patients with stage pT2-3N0-1M0 after radical treatment shows significantly poor prognosis,the long-term survival of which is closely related to the depth of infiltration,lymph node metastasis,intravascular cancer embolus and tumor diameter,which is worthy of further study.
Keywords：Esophagus carcinomaEsophagectomyCox's proportional hazards regression modelNomogramOverall survivalPrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1006-1011 )