Role of angiopoietin-2 in the control of malignant pleural effusion and prognosis in patients with primary lung adenocarcinoma
QIAN Qian
HU Wei
Abstract：Objective To investigate the role of angiopoietin-2 (Ang-2) in control of malignant pleural effusions (MPE) and prognosis in patients with primary lung adenocarcinoma.Methods Using enzyme-linked immunoadsorbentassay,the levels of Ang-2 were measured in both pleural effusions (PE) and serum from a total of 79 lung adenocarcinoma patients with MPE.Data was analyzed with the efficacy of MPE control and prognosis.Results The level of Ang-2 in PE was (26.67±8.82) pg/ml,and (361.18±97.58) pg/ml in serum.Ang-2 level in PE was the only one significant factor for MPE control when comparing with other demographic and laboratory data.Ang-2 ≥ 25.57 pg/ml in PE was used as a cut-off point for failure control of MPE.Logistic regression analysis showed that the level of Ang-2 in PE was an independent factor in the local control of PE (OR =5.65,95％ CI:2.40-16.78,P＜ 0.001).In a multivariate analysis,the level of Ang-2 in PE (HR=1.15,95％CI:1.01-1.32) and MPE control status (HR=0.42,95％CI:0.19-0.89) were confirmed as independent prognostic factors for overall survival.Conclusion The level of Ang-2 in PE appears to be a reliable surrogate marker in evaluating the therapeutic efficacy in the control of MPE and prognosis.
Keywords：Lung cancerMalignant pleural effusionAngiopoietin-2Therapeutic efficacyPrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 903-907 )