Expression and clinical significance of cancer stem cells related genes Bmi-1, POU5F1 in cervical cancer
LI Shiliang
JIANG Liping
ZHOU Miao
SHAO Guo'an
ZHANG Yuanyuan
GUZHALINUER Abulizi
Abstract：Objective To explore the expression of cancer stem cell related genes Bmi-1,POU5F1 in cervical cancer and their relationship with clinicopathological chracteristics.Methods The expression of Bmi-1,POU5F1 at mRNA level in 69 cervical cancer tissues and 16 cervical cancer tissues plus their para-carcinoma tissues were detected by real-time fluorescent quantitative PCR (QRT-PCR).Results The expression levels of Bmi-1 mRNA,POU5F1 mRNA in cervical cancer tissues were 1.51±0.05 and 1.75± 0.17,higher than 1.16±0.17 and 1.46±0.18 of their counterparts of the para-carcinoma tissues with statistically significant (P＜ 0.05).The relative ratio of level of Bmi-1 mRNA,POU5F1 mRNA was 1.31±0.49 and 1.20±0.95 between cervical cancer tissues and their para-carcinoma tissues.The expression of Bmi-1 mRNA was related with ethnic,lymph node metastasis,clinical staging and histological grade (P＜0.05),but not with age,tumor size and pathological type (P＞0.05).The expression of POU5F1 mRNA was related with ethnic,tumor size,lymph node metastasis,clinical staging and histological grade (P＜0.05),but not with age and pathological type (P＞0.05).Conclusion There was a relative high expression of Bmi-1,POU5F1 in cervical cancer.Bmi-1,POU5F1 expression may be associated with adverse biological characteristics of cervical cancer,and may seive as a potential indicator for molecular markers of cervical cancer biological behavior.
Keywords：Cervical cancerCancer stem cell related genesBmi-1POU5F1
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 633-636 )