Expression and clinical significance of E-cadherin and β-catenin in osteosarcoma tissues
BI Hu
YI Zhigang
PU Yanchuan
CHEN Bin
XU Donglin
Abstract：Objective To explore the expression and clinical significance of E-cadherin and β-catenin in osteosarcoma tissues.Methods From April 2012 to October 2015,54 specimens of osteosarcoma tissues and 22 specimens of osteochondroma tissues were enrolled.Immunohistochemistry was used to detect the expression of E-cadherin and β-catenin in those above tissues.The correlation of the expression of E-cadherin,β-catenin and clinical parameters of osteosarcoma were analyzed.Results In 54 specimens of osteosarcoma tissues,the positive rate of E-cadherin protein was 35.2％ (19/54),significantly lower than 68.2％ (15/ 22) in osteochondroma tissues (P＜0.05).However the positive rate of β-catenin protein was 68.5％ (37/54),significantly higher than 9.1％ (2/22) in osteochondroma tissues (P＜0.05).The expression of E-cadherin protein was associated with Enneking stage and metastasis (P＜0.05).The expression of β-catenin protein was associated with tumor size,Enneking stage and metastasis (P＜0.05).Moreover,the expression of E-cadherin and β-catenin was negatively correlated (r=-0.764,P＜0.05).Conclusion E-cadherin and β-catenin are abnormally expressed in osteosarcoma tissues,and they are correlated to Enneking stage and metastasis.Both of them play a role in the development and progression of osteosarcoma.
Keywords：OsteosarcomaE-cadherinβ-cateninImmunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 602-606 )