Value of 18F-FDG PET-CT imaging in predicting epidermal growth factor receptor mutations in unresectable lung adeocarcinoma
TANG Bo
DING Chongyang
LI Tiannv
Abstract：Objective To investigate the value of fluorodeoxyglucose F18 positron emission tomography-computed tomography (18F-FDG PET-CT) in predicting the presence of epidermal growth factor receptor (EGFR) mutations in unresectable lung adeocarcinoma.Methods From April 2012 to May 2016, 151 patients with stage ⅢB or Ⅳ lung adeocarcinoma who underwent 18F-FDG PET-CT and EGFR mutation analysis were enrolled in this study.Receiver-operating characteristic (ROC) curve was used to test the cut-off of maximum standard uptake value(SUVmax).Logistic regression model was employed to analyze the independent predictive factors for EGFR mutatuin.Results ROC curve showed that the cut-off of SUVmax was 10.28.Among 151 lung adeocarcinoma patients, 68(45.0%) were identified with EGFR mutation.Univariate analysis showed that gender, smoking status, CEA and SUVmaxwere all associated with EGFR mutation (P<0.05).And no significant differences were found regarding partical CT characteristics of lesions including cavitation, air bronchogram, attenuation, lobulation and pleural-indentation (P>0.05).Logistic multivariate analysis showed that smoking status and SUVmax were the independent factors for predicting EGFR mutation (P<0.05).Conclusion SUVmax of 18F-FDG PET/CT is an independent factor for predicting EGFR mutation in patients with unresectable lung adeocarcinoma, and it has certainly reference value for predicting EGFR mutation.
Keywords：Lung adeocarcinomaFluorodeoxyglucose F18 positron emission tomography-computed tomography (18F-FDG PET-CT)Epidermal growth factor receptor(EGFR)
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 526-530 )