Clinical observation on traditional Chinese medicine in combination with somatostatin analogues for advanced gastroenteropancreatic neuroendocrine tumors
LI Mei
DOU Dou
LUO Jie
ZOU Guoming
LIU Qing
TAN Huangying
Abstract：Objective To explore the efficacy and safety of traditional Chinese medicine(TCM) in combination with somatostatin analogues(SSA) therapy for advanced gastroenteropancreatic neuroendocrine tumors(GEP-NET).Methods From September 2011 to August 2015,39 patients with advanced GEP-NET who were treated in the Department of Integrative Oncology,China-Japan Friendship Hospital were enrolled in this study.Among 39 GEP-NET,19 were localized in pancreas,8 cases in rectum,8 cases in small intestine,1 case in stomach and 3 cases of primary unknown.All the patients received TCM plus SSA therapy.SSA was given as octreotide LAR(20mg,im,every 3-4 weeks) or Lanreotide(40 mg,im,every 10-14 days).At the same time,patients were treated with Chinese herb decoction according to syndrome differentiation.Efficacy was evaluated using RECIST 1.1 criteria every 3 months.Adverse events were evaluated according to NCI-CTC 3.0.The time to progression(TTP) was observed.Serum chromogranin A(CgA) was also monitored according to the schedule.Results A total of 39 cases were evaluated for efficacy including 20 cases of disease progression and 19 cases of stable disease with the objective response rate of 0 and disease control rate of 48.7%.The median TTP was 22.9 months.The main adverse events were cholelithiasis and 1 to 2 grade diarrhea.Conclusion TCM in combination with SSA treatment may significantly prolong the TTP for advanced GEP-NET with mild adverse effects,be worthy of further clinical application widely.
Keywords：Gastroenteropancreatic neuroendocrine tumors(GEP-NET)Somatostatin analogue(SSA)Traditional Chinese medicine(TCM)Chromogranin A(CgA)
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 238-242 )