Expression of Capn4 and Ki-67 in colon cancer and its clinical significance
WANG Donghua
JIA Xihua
ZHENG Shujun
ZHAO Xia
ZHANG Bingxin
WANG Xiaobo
Abstract：Objective To investigate the expression of calpain small subunit-1(Capn4) and nuclear proliferation marker(Ki-67) in colon cancer and its clinical significance.Methods Immunohistochemical method was used to detect the expression of Capn4 and Ki-67 in 70 cases of colon cancer and 35 cases of adjacent normal tissues.The relationship between the expression of Capn4 and Ki-67 and the clinicopathological features of colon cancer was analyzed.Results The positive expression rates of Capn4 and Ki-67 in colon cancer tissues were 74.3%(52/70) and 84.3%(59/70),which were significantly higher than 22.9%(8/35) and 17.1%(6/35) of adjacent normal tissues,and the difference was statistically significant(P<0.05).The expression of Capn4 and Ki-67 was closely related to the depth of invasion,TNM stage and lymph node metastasis(P<0.05),which was not related with age,sex and differentiation degree(P>0.05).The expression of Capn4 was positively correlated with Ki-67 in colon cancer tissues(r=0.734,P<0.05).Conclusion Capn4 and Ki-67 are highly expressed in colon cancer,and may be related to the occurrence and development of colon cancer.
Keywords：Colon cancerCapn4Ki-67Immunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 223-226 )