Clinical value of expression of thyroid hormone receptor mitochondrial P28 in benign and malignant thyroid tumor
LI Shiliang
SUN Fenfen
XU Lei
SHAO Guoan
MA Binlin
Abstract：Objective To explore the expression and clinical pathology of mitochondrial hormone receptor P28 mRNA( MT?P28 mRNA) in thyroid carcinoma tissue and nodular goiter tissue. Methods MT?P28 mRNA expression levels of 31 thyroid carcinoma tissues and 31 nodular goiter tissues were detected by quantitative PCR( QPCR) . Results The mRNA level of MT?P28 in the tissue of nodular goiter patients was 157±014, higher than 056±014 of its counterparts of the lesion side tissue with statistically significant (P<005). The mRNA level of MT?P28 in the thyroid cancer patients was 173±030, higher than 075±014 of the corresponding adjacent normal tissues with statistically significant( P<005) . MT?P28 mRNA level raised obviously in 31 cases of nodular goiter, and it was(265±064)times of that in the adjacent normal tissue, and the difference was statistically significant(P<005).The level of MT?P28 mRNA raised obviously in 31 cases of thyroid carcinoma compared to that of the para?tumorous tissue. The relative ratio of lev?el of MT?P28 mRNA was 420±073 between thyroid carcinoma tissue and their para?tumorous tissue, and the difference was statisti?cally significant( P<005) . MT?P28 mRNA was related with lymph node metastasis and clinical pathologicstaging( P<005) , but not with gender, age and tumor size( P>005) . Conclusion MT?P28 mRNA has different expression levels in benign and malignant thy?roid tumors. MT?P28 mRNA levels may have a promoting role in thyroid malignant lesions. It may serve as a diagnosis and differential diagnosis value for thyroid carcinoma.
Keywords：Thyroid carcinomaNodular goiterMitochondrial hormone receptor P28( MT?P28)QPCR
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 31-35 )