Research progress of circular RNAs and tumor
HOU Lidan
ZHANG Jing
Abstract：Circular RNA ( circRNA) as a newly discovered covalently closed circular non-coding RNA, is produced from back splicing and exists in a variety of biological cells, characterized by the stable structure, conserved sequence and some tissue-spe-cificity. Recent studies show that circRNAs function as microRNA sponges to inhibit miRNA activity, involving the regulation of gene transcription and binding with RNA-binding proteins. As the new regulatory molecules, circRNAs play an important role in tumor devel-opment and progression, and serve as the novel potential biomarkers,providing new strategies for cancer diagnosis and targeted therapy. Herein, we review the properties, biogenesis, and functions of circRNAs and discuss its role in cancer.
Keywords：TumorCircular RNAMicroRNAGene regulation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1043-1047 )