Prognostic analysis of PKM2 gene in breast cancer patients

ZHANG Shen; GONG Haibing; TAO Yuansheng

Abstract：Objective To explore the expression of PKM2 gene in breast cancer patients, and investigate the impact of PKM2 gene expression on prognosis of breast cancer. Methods Bioinformatics and free open gene chip data-set provided by Oncomine database and gene expression omnibus ( GEO) database were used to analyze the expression of PKM2 gene in breast cancer patients. The relationship between PKM2 gene and prognosis of breast cancer was analyzed depending on PKM2 expression level. Results Ex-pression level of PKM2 gene in breast cancer was significantly higher than that in normal breast tissue ( P<0. 05) . The disease-specific survival rate of breast cancer patients with high-expression of PKM2 gene were significantly lower than those with low-expression of PKM2 gene(HR=1. 897,95%CI:1. 117-3. 221, P<0. 05).The disease-free survival time and the recurrence-free survival time of breast cancer patients with high-expression of PKM2 gene was significantly shorter than those with low-expression of PKM2 gene( HR=1. 605, 95%CI:1. 050-2. 451, P=0. 029; HR=7. 377, 95%CI:1. 906-28. 548, P=0. 004). Conclusion PKM2 gene is high ex-pression in breast cancer, and the expression level of PKM2 has important significance in predicting the prognosis of breast cancer.