The long-term survival outcomes of 635 patients with locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiation therapy in non endemic area
WANG Tingting
SONG Dan
WU Lirong
YIN Li
HUANG Shengfu
HE Xia
Abstract：Objective To evaluate the long-term survival outcomes and prognostic factors of locoregionally advanced (Ⅲ,ⅣA,ⅣB) nasopharyngeal carcinoma( NPC) patients treated with intensity-modulated radiation therapy ( IMRT) plus chemotherapy in Jiangsu Province. Methods From January 2009 to December 2013, 635 locoregionally advanced NPC patients treated by IMRT and platinum-based chemotherapy were analyzed retrospectively. Survival data were calculated with a Kaplan-Meier method. Log-rank test and Cox proportional hazard regression model were performed to investigate the risk factors of prognosis. Results With a median fol-low-up of 63. 5 months ( range 5-92 months ) , the 5-year local recurrence-free survival ( LRFS ) , regional recurrence-free survival ( RRFS) , distant metastasis-free survival ( DMFS ) , disease-free survival ( DFS ) and overall survival ( OS ) rates were 88. 4%, 94. 2%, 79. 2%, 71. 9% and 76. 3%, respectively. Of the 635 patients, 175 ( 27. 6%) developed failure after treatment. Distant me-tastasis ( n=131, 74. 9%) was the major failure pattern after treatment. T stage was an independent prognostic factor for LRFS. N stage, clinical stage and chemotherapy were independent prognostic factors for RRFS, DMFS, DFS and OS. Conclusion IMRT pro-vides satisfactory long-term outcome for NPC. T and N stage are important prognostic factors, as well as chemotherapy.
Keywords：Locoregionally advanced nasopharyngeal carcinomaIntensity-modulated radiation therapy ( IMRT)Prog-nostic factors
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 994-1000 )