Expression of Maspin and Bmi-1 in nasopharyngeal carcinoma and their clinical significance
NING Haidan
LIANG Hai
LEI Ting
Abstract：Objective To investigate the expression of Maspin and Bmi-1 in nasopharyngeal carcinoma and their relationship with clinical pathological characteristics. Methods An immunohistochemical method was used to detect the expression of Maspin and Bmi-1 proteins in 60 nasopharyngeal carcinoma samples and 40 adjacent normal nasopharyngeal tissues. Then the relationship between Maspin, Bmi-1 expression and clinicopathological features was analyzed. Results The positive expression rate of Maspin in nasophary-negeal carcinoma and normal tissues was 45. 0%(27/60) and 90. 0%(36/40) with significant difference(P<0. 05). The positive ex-pression rate of Bmi-1 in nasopharyngeal carcinoma and normal tissues was 75. 0%(45/60) and 25. 0%(10/40), and the difference was statistically significant( P<0. 05) . The expression of Maspin and Bmi-1 was not correlated with the age( P>0. 05) , but with the de-gree of malignancy, lymph node metastasis and clinical stage (P<0. 05).The expression of Maspin and Bmi-1 in nasopharyngeal carci-noma showed significant negative correlation( r=-0. 406,P<0. 05) . Conclusion The expression of Maspin and Bmi-1 plays an impor-tant role in the occurrence and progression of nasopharyngeal carcinoma.
Keywords：Nasopharyngeal carcinomaMaspinBmi-1Immunohistochemistry
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 990-993 )