Expression and clinical significance of FAT10, NF-κB p50 in infiltrating ductal carcinoma of breast

CHEN Yanyan; YANG Chenggang; YE En

Abstract：Objective To investigate the expression of human leukocyte antigen F-associated transcript 10 ( FAT10) and nu-clear factor κB p50( NF-κB p50) in infiltrating ductal carcinoma of breast, and their relationship with clinicopathological characteris-tics. Methods FAT10 and NF-κB p50 expression in 112 patients with infiltrating ductal carcinoma of breast and in 53 breast non-can-cerous tissues were measured by immunohistochemistry. The relationship between FAT10, NF-κB p50 expression and clinicopathological features of infiltrating ductal carcinoma of breast were analyzed. Results The positive rate of FAT10 and NF-κB p50 expression in infiltrating ductal carcinoma of breast was 77. 68%(87/112) and 81. 25%(91/112) respectively, significantly higher than 39. 62%(21/53)and 45. 28%(24/53)in the non-cancerous tissues,and the difference was statistically significant (P<0. 001) . The expression of FAT10, NF-κB p50 was related to lymph node metastasis, distant metastasis and TNM stages of infiltrating ductal carcinoma of breast( P<0. 05) . But they had no obvious relation to age, tumor size and molecular type( P>0. 05) . The expres-sion of FAT10 was positively correlated with the expression of NF-κB p50(r=0. 624,P<0. 001). Conclusion The expression of FAT10, NF-κB p50 is closely associated with malignancy and invasive metastasis of infiltrating ductal carcinoma of breast. They may together promote tumor's occurrence and development.