Meta analysis of the association between miRNA-196a2 rs116149131 polymorphism and gastric cancer risk

GAO Jun; QIU Xiujuan; TANG Jianjun; WANG Jun; ZHOU Dong; LI Hengping

Abstract：Objective To evaluate the association between the microRNA ( miRNA)?196a2 rs116149131 gene polymorphism and susceptibility of gastric cancer. Methods All studies published up to March 2016 on the association between miRNA?196a2 rs116149131 gene polymorphism and susceptibility to gastric cancer were searched from PubMed, EMBASE, Cochrane library, CNKI, VIP, Wan fang and CBD database. The data were screened according to the inclusion and exclusion criteria, and extracted, and the quality of included studies was evaluated.The pooled odds ratios (OR) with 95% confidence intervals (95%CI) were calculated using Stata 12?0 software.Publication bias and sensitivity analysis were also assessed. Results A total of 9 studies involving 3992 cases and 5699 controls were included in the meta?analysis. The present meta?analysis showed no association between the miRNA?196a2 rs116149131 gene polymorphism and gastric cancer risk. In ethnic subgroup analysis, a strong association in heterozygous model ( CT vs. TT:OR=1?93, 95%CI:1?35?2?75, P<0?05) was found between rs11614913 and gastric cancer risk among Caucasians but no as?sociation in all models was found among Asians. In source of controls subgroup analysis, no association was found between rs11614913 and cancer risk among population?based (PB) and hospital?based (HB).In the subgroup of T<C, remarkably elevated gastric cancer risks were found in dominant model ( CT+CC vs. TT:OR=1?40, 95%CI:1?10?1?77, P=0?005) , homozygote model ( CC vs. TT:OR=1?59, 95%CI:1?22?2?06, P=0?001) and heterozygote model ( CT vs. TT:OR=1?33, 95%CI:1?04?1?70, P=0?025) . We did not find significant associations in recessive model and allele model. No association was found between rs11614913 and cancer risk in the subgroup of T>C. Conclusion miRNA?196a2 rs116149131 gene polymorphism and gastric cancer has no risk associated,but there are racial differences.