Expression of tumor infiltrating dendritic cells marked by CD1a and CD83 in breast cancer and its correla-tion with prognosis

WANG Minxue; LIU Shouyue; JIN Yongmin; CUI Xian; CUI Yan; CUI Hai; SHEN Xionghu; ZHANG Song-nan; SUN Honghua

Abstract：Objective To explore the expression of CD1a and CD83 marked tumor infiltrating dendritic cells(TIDC) in breast tissues and its correlation with prognosis. Methods Eighty?five cases of breast cancer tissues were collected and CD1a, CD83 expressions of breast cancer tissues were detected by immunochemical method. The relationship between their expression and clinico?pathological features and prognosis were analyzed. Results There were 77 cases with CD1a positive expression in 85 cases of breast cancer tissues, and most TIDC expressing CD1a were distributed in tumor tissues, and less expressed in tumor stroma and surrounding tissues;there were 44 cases with CD83 positive expression in 85 cases of breast cancer tissues, and TIDC expressing CD83 were ob?served in surrounding and interstitial tissues of tumors, with scattering distribution. There were 35 cases with CD1a and CD83 double positive expression. CD1a, CD83 double positive expression had no correlation with lymph node metastasis, progestrogen receptor( PR) and neutrophil?lymphocyte ratio(NLR)(P>0?05), but correlated with estrogen receptor(ER), HER?2 and TNM staging(P<0?05). The median disease?free survival( DFS) of patients with both CD1a, CD83 double positive expression and non?double positive expres?sion were not reached. Multivariate analysis indicated that non?double positive expression of CD1a, CD83 was an independent factor af?fecting prognosis of patients (HR=2?216,95%CI:1?682?3?431;P<0?05). Conclusion The expression of characteristic markers CD83 and CD1a of TIDC in breast cancer tissues are related with prognosis, and may be associated with immune escape mechanism of tumors, so they can be the reference indicators to detect the prognosis of breast cancer.