Correlation analysis between the expression of B7-H3 and the level of macrophages infiltration in hepatocel-lular carcinoma tissues
KANG Fubiao
WANG Ling
WANG Yan
PENG Huanyan
SUN Dianxing
Abstract：Objective To investigate the relationship between the expression of B7-H3 and the level of tumor-associated macrophages’(TAMs) infiltration in hepatocellular carcinoma(HCC) tissues. Methods The expression level of B7-H3 was detected by immunohistochemistry and quantitative Real-time PCR in 116 HCC tissues. Immunohistochemistry also was used to detect CD68 ex-pression. Then the relationship between B7-H3, CD68 expression and clinicopathologic features was analyzed. Results Among the 116 cancer tissues, the high expression rate of B7-H3 was 79. 3%( 92/116);and patients with the low, middle, high level of TAMs infil-tration were 21, 49 and 46 cases. The expression of B7-H3 was related to TNM stage, vascular invasion and microsatellite lesions for-mation( P<0. 05);The level of TAMs infiltration was related to TNM stage, vascular invasion, lymph node metastases and microsatel-lite lesions formation( P<0. 05) . The mRNA level of B7-H3 was significantly correlated with the level of TAMs infiltration ( r=0. 473,P<0. 001) . Conclusion The expression level of B7-H3 is positively correlated with the level of TAMs infiltration in HCC tissues, and they may contribute to the oncogenesis and progression of HCC.
Keywords：Hepatocellular carcinomaB7-H3Macrophages
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 613-616 )