Efficacy and safety of S-1 combined with compound kushen injection as first-line treatment in older patients with advanced gastric cancer
PIAO Ying
ZHENG Zhendong
TANG Ling
TAN Linshen
LIU Zhaozhe
ZHANG Guojing
XIE Xiaodong
Abstract：Objective To explore the effecacy and safety of S?1 plus compound kushen injection curative treatment for ad?vanced gastric cancer. Methods Sixty?three elderly patients over the age of 70 with gastric cancer from the general hospital of sheny?ang military region were enrolled, excluding 4 patients of disease progression and fall off. Fifty?nine patients in total according to ran?dom number table method were divided into 28 cases as the control group and 31 cases as combined group. The control group was taken S?1 orally(40 mg/m2), and combined group was taken S?1 plus compound kushen injection. The effecacy, adverse reactions and sur?vival were observed. Results The response rate( RR) and disease control rate( DCR) of combined group were 54. 9% and 90. 3%, which were similar with 39. 3% and 85. 7% of the control group( P>0. 05) . The main side effects were of grade 1?2 in both groups. The incidence of weakness and hepatic injury in combined group were 83. 9% and 74. 2%, lower than those in control group( 100. 0% and 96. 4%) , respectively( P<0. 05) . The median progression?free survival of combined group was 9. 0 months, higher than 7. 9 months in control group(P<0. 05). The median overall survival in combined group and control group was 14. 6 months and 13. 1 months(P>0. 05) . Conclusion S?1 combined with compound kushen injection for the treatment of elderly advanced gastric cancer has a longer progression?free survival with slight adverse reactions, worthy of clinical promotion.
Keywords：S-lCompound Kushen injectionElderlyAdvanced gastric cancerChemotherapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 535-539 )