Analysis of plasma OLFM4 level and its clinical significance in patients with non-small cell lung cancer

ZHU Kai; ZHANG Aiping; LIN Xiumin

Abstract：Objective To investigate the level of plasma OLFM4 in patients with non?small cell lung cancer( NSCLC) and its clinical significance. Methods The peripheral blood samples of 272 patients with NSCLC diagnosed in our hospital were collected and detected by enzyme?linked immunosorbent assay. The relationship between OLFM4 level and clinical pathological parameters( sex, age, tumor size, differentiation type, clinical stage, T stage, smoking history and lymph node metastasis) were analyzed. Meanwhile, the peripheral blood samples from 300 healthy subjects were selected as control. The OLFM4 levels of 156 NSCLC tissue samples were de?tected. The correlation between tissue and plasma levels of OLFM4 was analyzed using Person correlation analysis. Efficacy of plasma OLFM4 levels in the early diagnosis of NSCLC was evaluated using receiver operating characteristic curve ( ROC ) . Results The OLFM4 level of NSCLC group was(77. 39±15. 13)μg/ml, higher than(14. 56± 6. 94)μg/ml of control group with statistical signifi?cance( P<0. 05) . The level of OLFM4 was related to the tumor size, TNM stage, T stage and lymph node metastasis of NSCLC. The patents with tumor size greater than 3 cm,Ⅲ?ⅣTNM stage, T3?T4 stage and lymph node metastasis had a higher plasma OLFM4 lev?els than their corresponding subjects( P<0. 05) . Plasma levels of OLFM4 were positively correlated with tissue( r=0. 641, P<0. 05) . The area under the curve of plasma OLFM4 level in the diagnosis of NSCLC was 0. 862(95%CI: 0. 752?0. 937). The optimal cut?off value was 27. 11 μg/ml with the sensitivity and specificity rates of 81. 3% and 77. 4%, indicating a better value in the early diagnosis of NSCLC. Conclusion OLFM4 is highly expressed in the plasma of patients with NSCLC, and it is related to tumor size, clinical stage and lymph node metastasis. It may have a certain role in the occurrence and development of NSCLC, and it has good value in the early diagnosis of NSCLC.