Progession of the experimental and clinical research of 5-aminolevulinic acid-based photodynamic and sono-dynamic therapy of tumor
XU Tongying
ZHU Wenting
XIE Rui
WEI Xiaoli
LI Yanjing
BAI Yuxian
Abstract：5-aminolevulinic acid(5-ALA) is a strong photosensitizer, and it is widely used in photodynamic and sonodynamic therapy. 5-ALA is a precursor of PpⅨ which is generally accumulated higher in tumor cells than normal cells. Irradiation and ultra-sound irradiation excitate PpⅨ in tumor cells and produce reactive oxygen species(ROS), and damage DNA, mitochondria membrane and the other cell membrane then causes the apoptosis, necrosis. This article reviews the experimental and clinical research progression of 5-ALA in photodynamic and sonodynamic therapy of tumor recent years.
Keywords：5-aminolevulinic acid(5-ALA)Photodynamic therapySonodynamic therapyTumor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 469-473 )