Influence of biological characteristics of breast cancer in mammography on surgical margin status of breast-conserving surgery

ZHAO Kaihua; LI Peiying; GONG Lei; XU Jing; TAN Zhengshuai; LIU Songling; WANG Binggao; YAN Zheng

Abstract：Objective To explore the influence of biological characteristics of breast cancer in mammography on surgical mar-gin status of breast-conserving surgery. Methods One hundred and twenty patients diagnosed with stage Ⅰ or Ⅱ primary breast canc-er received breast-conserving surgery were enrolled in this study. According to the mammography images, the breast cancer patients were divided into five groups, including masses type group, mass associated with calcification type group, calcification type group, a-symmetries type group and architectural distortion type group. Total excision of breast lumps and surrounding tissue were performed a-bout 1 cm. Intraoperative rapid pathological was employed to determine the initical state of cutting edge, which was confirmed by paraf-fin pathology. The relationship between biological characteristics of breast cancer in mammography and surgical margin status was ana-lyzed. Results Pathologic features including age, tumor size, grade, nodal metastases, estrogen receptor status, progesterone receptor status and HER-2 expression were not associated with margin status of breast cancer patients. The positive rate of patients with tumor thrombus in vascular was 26. 3% (5/ 19), higher than 6. 9% (7/ 101) of patients without tumor thrombus in vascular with statistical significance (P<0. 05). No statistically significant difference was observed on the initial surgical margin status among five groups ac-cording to mammography classification. As for isolated malignant carcinoma, surgical margin status was not correlated with imaging characteristics of the tumor. However, mixed malignant carcinoma was significantly correlated with the margin status (P = 0. 005). Conclusion For breast-conserving surgery, we may need to consider characteristics of the tumor mammography classification and esti-mate pathological type in order to reduce the probability of positive margin.