The correlation and expressions of Fn14, p-JAK2 and p-STAT3 in esophageal squamous cell carcinoma

LIU Kai; LI Xiaofei; ZHANG Zhipei; SUN Ying

Abstract：Objective To investigate the role of Fn14 with JAK2/ STAT3 pathway in esophageal squamous cell carcinoma (ESCC), and the expression of JAK2/ STAT3 molecules were detected and the correlation of Fn14 with JAK/ STAT was discussed. Methods Fn14,p-JAK2 and p-STAT3 expressions in tumor tissues were assessed using immunohistochemical(IHC) methods in 118 patients with resected ESCC, and the correlation of Fn14 expression with JAK2/ STAT3 expression was analyzed. Results The expres-sion of Fn14 was mainly located on cell membrane and the expression of p-JAK2, p-STAT3 were mainly located in cytoplasm and cell nucleus. The positive expression rates of Fn14, p-JAK2 and p-STAT3 protein in ESCC were 51. 7%(61/ 118), 50. 9%(60/ 118) and 57. 6%(68/ 118), which were higher than 4. 2%(5/ 118) of corresponding adjacent non-cancerous tissue with statistical difference(P<0. 05). There were significant differences for Fn14, p-JAK2, p-STAT3 expressions in pathological grades and TNM stages groups(P<0. 05), while there were no significant differences for Fn14, p-JAK2, p-STAT3 in sex and age (P>0. 05). The correlation of Fn14 with p-JAK2, p-STAT3 were obvious in pathological grades and TNM stages in ESCC(P<0. 05). Conclusion The Fn14, p-JAK2, p-STAT3 proteins were highly expressed in ESCC, which suggest that Fn14, p-JAK2, p-STAT3 would be likely to be associated with the development of ESCC.