Clinical analysis of 13 patients with primary breast diffuse large B cell lymphoma

LIU Xiaowu; LI Nan; BIAN Jianjun

Abstract：Objective To explore the clinical features,diagnosis and treatment of 13 patients with primary breast diffuse large B cell lymphoma ( PB-DLBCL) . Methods The clinical data of 13 patients with PB-DLBCL from Jan 2010 to Nov 2015 were retro-spectively analyzed. Eight cases received breast mass excision, 4 cases underwent modified radical mastectomy, and 1 case received u-nilateral mastectomy. Results All of the cases were female. The involved breasts were left-sided in 6 cases, right-sided in 6 cases, and bilateral breast was found in 1 case. The size ranged from 1. 5 cm to 8. 0 cm. Two cases were preoperatively diagnosed as breast fi-broadenoma, 1 case as giant fibroadenoma, and 10 cases as breast carcinoma. Thirteen cases were diagnosed as PB-DLBCL by using immunohistochemistry. According to Ann Arbor staging, 10 cases were in stageⅠ, and 3 cases were in stageⅡ. Twelve cases received chemotherapy of CHOP or R-CHOP regimen after operation, and 1 case gave up treatment. The follow-up time ranged from 1 month to 5 years. During follow-up, 2 cases relapsed, 2 cases died, and 9 cases survived without relapse. Conclusion PB-DLBCL is not common in clinic, and mainly occurs in female. PB-DLBCL is easily misdiagnosed by preoperative examination and intraoperative frozen section, and the exact diagnosis is confirmed by immunochemistry. Chemotherapy based comprehensive treatment is the main method for PB-DLBCL.