Research progression of treatment of advanced colorectal cancer with Braf mutation
WEI Qing
WANG Xicheng
SHEN Lin
Abstract：With increasing knowledge of the molecular subtypes and target therapy of colorectal cancer, more and more efforts have therefore focused on mitogen?activated protein kinase signaling ( MAPK) pathway. V?raf murine sarcoma viral oncogene homolog B ( Braf) is a principal downstream effector of MAPK pathway, and plays an important role in cancer development and progress. This arti?cle will review the role of Braf mutation in metastatic colorectal cancer, with emphasis on molecular and clinico?pathological character?istics, and current difficulties and progresses in treatment of colorectal cancer for reference.
Keywords：Colorectal cancerBraf mutationTarget therapyChemotherapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 282-286 )