Efficacy evaluation of sorafenib in the treatment of hepatocellular carcinoma combined with peripheral cir-culating tumor cells:Two cases report
LONG Jianyun
ZI Xiaoyuan
LI Jing
HUANG Liang
CAO Jie
YAN Yiqun
Abstract：Objective To evaluate the efficacy of sorafenib in the treatment of hepatocellular carcinoma( HCC) through com?bined with peripheral circulating tumor cell( CTC) and to improve the recognition of CTC in HCC. Methods CTCs of two HCC pa?tients were isolated by SET?iFISH technique and were identified by i?FISH. Then we analyzed the patients? clinical manifestation and long?term survival with CTC. Results CTCs of HCC were marked as CK-/DAPI+/FISH(CEP8 single)+/CD45-. We separated 2 patients? peripheral blood (7?5 ml) in three consecutive days. Patient 1 had 2 CTCs, however, we had not found CTC in patient 2? s blood. Till now, patient 2 have disease?free survival of 13 months. Conclusion Combination with CTCs can be an effective and nonin?vasive method to analyze the efficacy of sorafenib in the treatment of HCC. It can provide a new prospect in the diagnosis and treatment of HCC.
Keywords：Hepatocellular carcinoma ( HCC)Circulating tumor cell ( CTC)Sorafenib
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 275-277 )