Expression of HOXD3 in triple-negative breast cancer and its relationship with clinical pathological factors and prognosis
LV Xinxin
LI Cong
REN Yanlv
ZHANG Qingyuan
LI Zhigao
ZHANG Yue
CHENG Shaoqiang
Abstract：Objective To investigate the expression of HOXD3 in triple?negative breast cancer ( TNBC) and its relationship with clinical pathological factors and prognosis. Methods The expression of HOXD3 was detected in 89 TNBC tissues by immunohis?tochemical staining and compared with the clinicopathological features and the prognosis. Results The positive expression rate of HOXD3 in TNBC was 69?7%(62/89), and it was closely associated with histological grade and NPI. The medium disease?free survival and overall survival of patients with positive HOXD3 expression were lower than those of patients with negative HOXD3 expression. Uni?variate and multivariate analyses showed that HOXD3 was an independent unfavorable prognostic factor for patients with TNBC. Con?clusion HOXD3 can be used as a potentially useful prognostic marker for TNBC.
Keywords：HOXD3Triple-negative breast cancerSurvivalPrognosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 223-227 )