Research progress of p44/WDR77 gene in non-small cell lung cancer
CUI Yuanbo
ZHANG Zhipei
WANG Xuejiao
WANG Wuping
GU Zhongping
Abstract：Lung cancer is the leading cause of cancer deaths throughout the world. Non?small cell lung cancer ( NSCLC) is the most common type of lung cancer. However, its pathogenesis has not been elucidated. Recently, researches have shown that p44/WDR77 expression is essential for the growth of lung epithelial cells and orthotropic lung adenocarcinoma tumors. The expression of 44?KDa androgen receptor cofactor/WD repeat domain 77 ( p44/WDR77) gene in NSCLC is significantly higher than that in adjacent tis?sues. Loss of p44/WDR77 expression in lung epithelial cells and lung adenocarcinoma cancer cells leads to G1 cell cycle arrest via the p21?Rb?E2F signaling pathway. P44/WDR77 was re?expressed in lung cancer, and silencing p44/WDR77 expression strongly inhibited growth of lung adenocarcinoma tumor xenografts in mice. This article will briefly summarize the research progresses of p44/WDR77 in NSCLC.
Keywords：44-KDa androgen receptor cofactor/WD repeat domain 77Non-small cell lung cancerMolecular mecha-nism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1049-1052 )